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Bis[platinum(II)] complexes for intermolecular DNA binding

✍ Scribed by Janina Altman; Elfriede Schuhmann; Konstantin Karaghiosoff; Wolfgang Beck


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
52 KB
Volume
59
Category
Article
ISSN
0162-0134

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A new series of DNA binding 5,10,15-tri(N-methyl-4-pyridiniumyl)porphyrin (TrisMPyP)-platinum(II) conjugates was synthesized, in which different spacer ligands were used for appropriate coordination to platinum(II) complexes. Compound 9b exhibited in vivo antitumor activity (T/C%, 294) superior to c