𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8+ T cells

✍ Scribed by Ian R. Humphreys; Seung-Woo Lee; Morgan Jones; Andrea Loewendorf; Emma Gostick; David A. Price; Chris A. Benedict; Carl F. Ware; Michael Croft

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
296 KB
Volume
40
Category
Article
ISSN
0014-2980

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The initial requirement for the emergence of CMV‐specific CD8^+^ T cells is poorly understood. Mice deficient in the cosignaling TNF superfamily member, 4‐1BB, surprisingly developed exaggerated early CD8^+^ T‐cell responses to mouse CMV (MCMV). CD8^+^ T cells directed against acute MCMV epitopes were enhanced, demonstrating that 4‐1BB naturally antagonizes these primary populations. Paradoxically, 4‐1BB‐deficient mice displayed reduced accumulation of memory CD8^+^ T cells that expand during chronic/latent infection. Importantly, the canonical TNF‐related ligand, 4‐1BBL, promoted the accumulation of these memory CD8^+^ T cells, whereas suppression of acute CD8^+^ T cells was independent of 4‐1BBL. These data highlight the dual nature of the 4‐1BB/4‐1BBL system in mediating both stimulatory and inhibitory cosignaling activities during the generation of anti‐MCMV immunity.

πŸ“œ SIMILAR VOLUMES

Expression and function of 4-1BB during
Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivo
✍ Wojciech Dawicki; Tania H. Watts πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 334 KB πŸ‘ 2 views

## Abstract 4‐1BBL^–/–^ mice have a defect in recall CD8^+^ T cell responses to viruses, whereas CD4^+^ T cell responses to virus are unimpaired in these mice. In contrast, both CD4^+^ and CD8^+^ T cells respond to 4‐1BB ligand (4‐1BBL) __in vitro__. To clarify the role of 4‐1BB/4‐1BBL in CD4^+^ ve

The role of epigenetics in the acquisiti
The role of epigenetics in the acquisition and maintenance of effector function in virus-specific CD8 T cells
✍ Matthew R. Olson; Brendan E. Russ; Peter C. Doherty; Stephen J. Turner πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 153 KB

## Abstract CD8^+^ T cells are critical for protecting the body from infectious disease. To achieve this protection, CD8^+^ T cells must undergo a highly involved process of differentiation that involves the activation of naΓ―ve/quiescent cells followed by robust rounds of cell division and the acqu