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The role of epigenetics in the acquisition and maintenance of effector function in virus-specific CD8 T cells

✍ Scribed by Matthew R. Olson; Brendan E. Russ; Peter C. Doherty; Stephen J. Turner

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
153 KB
Volume
62
Category
Article
ISSN
1521-6543

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✦ Synopsis

Abstract

CD8^+^ T cells are critical for protecting the body from infectious disease. To achieve this protection, CD8^+^ T cells must undergo a highly involved process of differentiation that involves the activation of naïve/quiescent cells followed by robust rounds of cell division and the acquisition of effector functions that mediate viral clearance. After the pathogen is eliminated, a small number of these cells survive into long‐lived memory and maintain the capacity to respond rapidly and reacquire effector function after secondary exposure to their cognate antigen. This review focuses on how CD8^+^ T cells acquire and regulate effector functions and how the capacity to produce effector molecules is maintained into memory. © 2010 IUBMB IUBMB Life 62(7): 519–526, 2010

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## Abstract Activation of mature CD8^+^ T cells requires recognition, __via__ the T cell receptor (TCR), of peptide + MHC (pMHC) complexes with an avidity that exceeds a designated threshold. Multiple indicators of T cell avidity have been described that provide unique information on the characteri