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Biotransformation of α-bromo and α,α′-dibromo alkanone to α-hydroxyketone and α-diketone by Spirulina platensis
✍ Scribed by Takamitsu Utsukihara; Shinnosuke Okada; Nakahide Kato; C. Akira Horiuchi
- Book ID
- 113804156
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 292 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1381-1177
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📜 SIMILAR VOLUMES
Amino-substituted aryhnethylketones are selectively brominated in sulfuric acid to afford the corresponding dibromomethylarylketones that are then debrominated with diethylphosphite to give the desired bromomethylarylketones in excellent yield.
Ynolates have been synthesized via the thermally-inducedcleavage of ester dianions. The key intermediates, ester dianions, were generated from ~t -bromocarboxylic acid ester enolates via lithium halogen exchange, ot,~-Dibromocarboxylic acid ester also gives lithium amide free ynolates by addition of
Novel Synthesis of Ynolates via the Cleavage of Ester Dianions: α-Bromo and α,α-Dibromo Esters as Precursors. -Thermal cleavage of ester dianions generated from readily available α-bromo-and α,α-dibromo esters offers a new and convenient method to prepare lithium ynolates. The ynolates react with al