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A facile protocol for the convenient preparation of amino-substituted α-bromo- and α,α-dibromo arylmethylketones

✍ Scribed by Zhenjun Diwu; Christopher Beachdel; Dieter H. Klaubert

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 288 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)00975-7

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✦ Synopsis

Amino-substituted aryhnethylketones are selectively brominated in sulfuric acid to afford the corresponding dibromomethylarylketones that are then debrominated with diethylphosphite to give the desired bromomethylarylketones in excellent yield.

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