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Biosynthetic 14C-labelling of xanthohumol in hop cones

✍ Scribed by Stefanie Berwanger; Norbert Frank; Jutta Knauft; Hans Becker

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 148 KB
Volume: 49
Category: Article
ISSN: 1613-4125
DOI: 10.1002/mnfr.200500040

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✦ Synopsis

Xanthohumol (Xn) has well-established chemopreventive potential in vitro. In order to carry out in vivo bioavailability and tissue distribution studies,( 14)C-labelled Xn was produced by biolabelling. Supplying hop sprouts with 5 mCi [U-(14)C]glucose led to incorporation of (14)C into Xn. Delivering the radioactive precursor at once resulted in Xn with a specific activity of 318 microCi.mmol(-1); if however the amount was supplied in aliquots over 4 days a specific activity of only 53.1 microCi.mmol(-1) Xn was obtained.

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