Nystatin,the most commonly used clinical polyene macrolide antifungal antibiotic from Streotomyces noursei', and first discovered member of this group of natural products,has rather long record of chemical studies.It was generally characte-
Biosynthesis of the polyene macrolide antibiotic nystatin inStreptomyces noursei
✍ Scribed by Espen Fjærvik; Sergey B. Zotchev
- Book ID
- 105949899
- Publisher
- Springer
- Year
- 2005
- Tongue
- English
- Weight
- 232 KB
- Volume
- 67
- Category
- Article
- ISSN
- 1432-0614
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Complete mass spectra of the pertrimethylsilylated derivatives of three high molecular weight polyene macrolide antibiotics are reported for the first time. The fragmentation pathways which are proposed have been corroborated by the stable isotope derivatives d,-TMS and d,-acetyl. Accurate mass meas
Ikeda, Suzuki and Djerassi' extended previous joint work 2,3 on nystatin, the chemotherapeutically-important antifungal agent4 from Streptomyces noursei', and proposed constitution (I; R = OH) for nystatinolide, its hypothetical aglycone. This structure (I; R = OH) corresponds to C41H64015' and with