Biosynthesis of the neurotoxin β-N-oxalyl-α,β-diaminopropionic acid in callus tissue of Lathyrus sativus
✍ Scribed by Yu-Haey Kuo; Fernand Lambein
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 482 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0031-9422
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📜 SIMILAR VOLUMES
A sensitive color reaction ofo-phthalaldehyde (OPT) with a$-diaminopropionic acid (DAP) is described. The reaction is used to determine specifically the DAP content in tissues ofthe rat injected with this amino acid. The method indicated the presence in the liver and kidney of a alkali labile metabo
p-N-Oxalyl-L-a$-diaminopropionic acid (P-L-ODAP) is thought to be the causative agent in lathyrism due to its neuroexcitatory and neurotoxic properties. We have recently reported that P-L-ODAF' is also gliotoxic at high concentrations (Bridges et al.: Brain Res 561:262, 1991). Evidence is now presen