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Biosynthesis of Isoprenoids. A Rapid Method for the Preparation of Isotope-Labeled 4-Diphosphocytidyl-2 C -methyl- d -erythritol

โœ Scribed by Rohdich, Felix; Schuhr, Christoph A.; Hecht, Stefan; Herz, Stefan; Wungsintaweekul, Juraithip; Eisenreich, Wolfgang; Zenk, Meinhart H.; Bacher, Adelbert


Book ID
127363811
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
68 KB
Volume
122
Category
Article
ISSN
0002-7863

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Free 2-C-methyl-d-erythritol is utilised for isoprenoid biosynthesis by Escherichia coli mutants lacking the two ยฎrst enzymes of the methylerythritol phosphate pathway, the deoxyxylulose phosphate synthase and isomero-reductase. For feeding experiments, this tetrol was synthesised with an overall 43