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Biosynthesis of 20-hydroxyecdysone in Ajuga hairy roots: Stereochemistry of C-25 hydroxylation

✍ Scribed by Takayoshi Nakagawa; Noriyuki Hara; Yoshinori Fujimoto

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 208 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)00433-4

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✦ Synopsis

Feeding of [13C2]acetate to hairy roots of Ajuga reptans var. atropurpurea followed by 13C.NM R analysis of the biosynthesized cholesterol and 20-hydroxyecdysone indicated that C-25 hydroxylation in 20-hydroxyecdysone biosynthesis proceeds both in retention and inversion mechanisms. Feeding studies of [26 -13C]-and [27-13C]cholesterols established that the ratio of retention and inversion mechanisms is ca. 3:1.

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