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Biosynthesis of [[14C]PATULIN BY PENICILLI-UM URTICAE,

โœ Scribed by Eisele, Thomas A.; Pierce, Terry S.; Branen, A. Larry; Swanson, Barry G.

Book ID
126968079
Publisher
American Chemical Society
Year
1980
Tongue
English
Weight
71 KB
Volume
28
Category
Article
ISSN
0021-8561

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Antibiotic production by submerged cultures of Penicilliwn urtioae required manganese supplementation of the media. Thus, manganese supplementation (152 uM) allowed accumulation of patulin to high concentrations (2 ~mol/mL), whereas manganese deficiency (1.53 ~M) resulted in the accumulation to simi

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## Conidia of ~enicilZ<um urticae, immobilized in k-carrageenan beads, were germinated in situ to form a patulin producing cell mass by incubating these beads in a growth supporting medium. When these in s?:tu grown immobilized cells were repeatedly transferred and incubated in a nitrogenfree prod