Semi-continuous production of the antibiotic patulin by immobilized cells ofPenicillium urticae

✍ Scribed by Y. M. Deo; G. M. Gaucher

• Publisher: Springer Netherlands
• Year: 1983
• Tongue: English
• Weight: 774 KB
• Volume: 5
• Category: Article
• ISSN: 0141-5492
• DOI: 10.1007/bf00132171

✦ Synopsis

Conidia

of ~enicilZ<um urticae, immobilized in k-carrageenan beads, were germinated in situ to form a patulin producing cell mass by incubating these beads in a growth supporting medium. When these in s?:tu grown immobilized cells were repeatedly transferred and incubated in a nitrogenfree production medium the,y exhibited a greater than three fold increase in the half-life of patulin production as compared with similarly treated free cells.

When conidia were first germinated and grown to form a free cell mass and then immobilized, both the half-life and total patulin production were much less than that for free cells or in situ grown immobilized cells.