Biosafety Features of Lentiviral Vectors
β Scribed by Schambach, Axel; Zychlinski, Daniela; Ehrnstroem, Birgitta; Baum, Christopher
- Book ID
- 118749030
- Publisher
- Mary Ann Liebert
- Year
- 2013
- Tongue
- English
- Weight
- 242 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1043-0342
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π SIMILAR VOLUMES
Vectors derived from retroviridae offer particularly flexible properties in gene transfer applications given the numerous possible associations of various viral surface glycoproteins (determining cell tropism) with different types of retroviral cores (determining genome replication and integration).
## Background Lentiviral vectors are efficient vehicles for stable gene transfer in dividing and non-dividing cells. Several improvements in vector design to increase biosafety and transgene expression, have led to the approval of these vectors for use in clinical studies. Methods are required to a