## Abstract Angiogenesis is a rateβlimiting factor for numerous human diseases. Angiogenic vessels and also the endothelium of certain organs such as the lung display molecular addresses that can be exploited for the selective delivery of gene therapeutics. Lentiviral vectors (LVs) are powerful too
Visualization of targeted transduction by engineered lentiviral vectors
β Scribed by Joo, K-I; Wang, P
- Book ID
- 109855192
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 970 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0969-7128
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π SIMILAR VOLUMES
Vectors derived from retroviridae offer particularly flexible properties in gene transfer applications given the numerous possible associations of various viral surface glycoproteins (determining cell tropism) with different types of retroviral cores (determining genome replication and integration).
Gene transfer vectors based on retroviruses including oncogenic retroviruses and lentiviruses provide effective means for the delivery, integration and expression of exogenous genes in mammalian cells. Lentiviral (LV) vectors provide attractive gene delivery vehicles in the context of non-dividing c