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Biopolymer Synthesis on Polypropylene Supports: I. Oligonucleotides

✍ Scribed by R.S. Matson; J.B. Rampal; P.J. Coassin

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
463 KB
Volume
217
Category
Article
ISSN
0003-2697

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✦ Synopsis

We have modified polypropylene to serve as a new solid-phase support for oligonucleotide synthesis. The plastic is first surface aminated by exposure to an ammonia plasma generated by radiofrequency plasma discharge. The aminated polypropylene has been found to be useful as a support for the in situ synthesis of oligonucleotides from monomers. Furthermore, oligonucleotides synthesized on the surface of the plastic remain attached following deprotection and can be used directly for hybridization. 1994 Academic Press, Inc.

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