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Biophysical and Pharmacological Properties of Large Conductance Ca2+-Activated K+ Channels in N1E-115 Cells

✍ Scribed by M. Diserbo; B. Antonny; J. Verdetti

Book ID
115575733
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
411 KB
Volume
205
Category
Article
ISSN
0006-291X

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The effect of pinacidil, an opener of ATP-sensitive K + (K ATP ) channels, on large-conductance Ca 2+ -activated K+ (BK Ca ) channels was investigated in cultured endothelial cells of human umbilical veins. In whole cell configuration, pinacidil (30 Β΅M) increased the amplitude of K + outward current