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Activation of Large Conductance Ca2+-Activated K+Channels in N1E-115 Neuroblastoma Cells by Platelet-Activating Factor

✍ Scribed by Michel Diserbo; Marc Fatôme; Jean Verdetti

Book ID
115577929
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
58 KB
Volume
218
Category
Article
ISSN
0006-291X

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The effect of pinacidil, an opener of ATP-sensitive K + (K ATP ) channels, on large-conductance Ca 2+ -activated K+ (BK Ca ) channels was investigated in cultured endothelial cells of human umbilical veins. In whole cell configuration, pinacidil (30 µM) increased the amplitude of K + outward current