The effect of pinacidil, an opener of ATP-sensitive K + (K ATP ) channels, on large-conductance Ca 2+ -activated K+ (BK Ca ) channels was investigated in cultured endothelial cells of human umbilical veins. In whole cell configuration, pinacidil (30 µM) increased the amplitude of K + outward current
✦ LIBER ✦
Neuropeptide Y2-type receptor-mediated activation of large-conductance Ca2+-sensitive K+channels in a human neuroblastoma cell line
✍ Scribed by Virginia Soares Lemos; Kenneth Takeda
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 811 KB
- Volume
- 430
- Category
- Article
- ISSN
- 0031-6768
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## Abstract The effects of rottlerin, a known inhibitor of protein kinase C‐δ activation, on ion currents were investigated in pituitary tumor (GH~3~) cells. Rottlerin (0.3–100 µM) increased the amplitude of Ca^2+^‐activated K^+^ current (I~K(Ca)~) in a concentration‐dependent manner with an EC~50~