Biomimetically Inspired Total Synthesis and Structure Activity Relationships of 1- O -Methyllateriflorone. 6π Electrocyclizations in Organic Synthesis

“Biomimetic” Cascade Reactions in Organi

“Biomimetic” Cascade Reactions in Organic Synthesis: Construction of 4-Oxatricyclo[4.3.1.0]decan-2-one Systems and Total Synthesis of 1-O-Methylforbesione via Tandem Claisen Rearrangement/Diels–Alder Reactions

✍ K. C. Nicolaou; Jim Li 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 133 KB 👁 2 views

A further demonstration of the value of "biomimetically" inspired synthetic strategies toward natural products is provided by the title reactions that were developed for the construction of 4-oxatricyclo[4.3.1.0]decan-2-one systems from prochiral aromatic precursors. This biomimetic cascade was appl

“Biomimetic” Cascade Reactions in Organi

“Biomimetic” Cascade Reactions in Organic Synthesis: Construction of 4-Oxatricyclo[4.3.1.0]decan-2-one Systems and Total Synthesis of 1-O-Methylforbesione via Tandem Claisen Rearrangement/Diels–Alder Reactions

✍ K. C. Nicolaou; Jim Li 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 137 KB 👁 2 views

Synthesis of Calystegine B2, B3, and B4

Synthesis of Calystegine B2, B3, and B4 Analogues: Mapping the Structure-Glycosidase Inhibitory Activity Relationships in the 1-Deoxy-6-oxacalystegine Series

✍ M. Isabel García-Moreno; Carmen Ortiz Mellet; José M. García Fernández 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 323 KB 👁 1 views

## Abstract A practical synthesis of ring‐modified calystegine analogues with a 6‐oxa‐__nor__‐tropane structure has been developed. The methodology relies on the ability of the masked carbonyl group of hexose precursors to act as the electrophilic target for the nitrogen atom of pseudoamide (urea o

Serotonin 5-HT6receptor antagonists. II.

Serotonin 5-HT6receptor antagonists. II. Synthesis and structure—activity relationship of 3-arylsulfonyl-2-methylthiopyrazolo[1,5-a]pyrimidines with substituents containing an amine in the 6-position

✍ Ivachtchenko, A. V.; Golovina, E. S.; Kadieva, M. G.; Kysil, V. M.; Mitkin, O. D 📂 Article 📅 2012 🏛 Springer 🌐 English ⚖ 164 KB

Synthesis, in Vitro Pharmacology, Struct

Synthesis, in Vitro Pharmacology, Structure−Activity Relationships, and Pharmacokinetics of 3-Alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent and Selective Group II Metabotropic Glutamate Receptor Antagonists

✍ Nakazato, Atsuro; Sakagami, Kazunari; Yasuhara, Akito; Ohta, Hiroshi; Yoshikawa, 📂 Article 📅 2004 🏛 American Chemical Society 🌐 English ⚖ 215 KB

Structure−Activity Relationship of 3-Sub

Structure−Activity Relationship of 3-Substituted N -(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11 H -benzo[5,6]cyclohepta[1,2- b ]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor Compounds

✍ Njoroge, F. George; Vibulbhan, Bancha; Rane, Dinananth F.; Bishop, W. Robert; Pe 📂 Article 📅 1997 🏛 American Chemical Society 🌐 English ⚖ 411 KB