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Biomedical modification of poly(L-lactide) by blending with lecithin

✍ Scribed by N. Zhu; F.Z. Cui; K. Hu; L. Zhu

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
327 KB
Volume
82A
Category
Article
ISSN
1549-3296

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✦ Synopsis

Abstract

Lecithin was, for the first time, blended with PLLA to prepare scaffold material for tissue engineering applications in the present study. Solution blending was used to incorporate Lecithin (containing 0–10 wt %) with PLLA to enhance the blend films biocompatibility, hydrophilicity and toughness while maintaining mechanical strength of PLLA. The results of FTIR‐ATR analysis indicated that the amino groups of lecitin existed in the films. DSC analysis indicated that T~g~ decreased with the increase of lecithin content in the blend films. The percentage elongation markedly increased with increase of lecithin content. The proliferation and viability of the vascular smooth muscle cell cultures on PLLA/Lecithin (containing 3–7 wt %) films were significantly enhanced compared to pure PLLA on tissue culture plates. Β© 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2007

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## Abstract Poly‐L‐lactide (PLLA) has been used to prepare scaffolds to guide tissue regeneration in tissue engineering research. However, one of the limitations to the use of PLLA as an ideal biomaterial is its high hydrophobicity. To improve the hydrophilicity of PLLA, hydrophilic polymers were g