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Biologically active glycosides from asteroidea, XXXII. Glycosphingolipids from the starfishAstropecten latespinosus, 2. Structure of two new ganglioside molecular species and biological activity of the ganglioside

✍ Scribed by Higuchi, Ryuichi ;Matsumoto, Shuji ;Fujita, Masanori ;Komori, Tetsuya ;Sasaki, Takuma

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
633 KB
Volume
1995
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

Two ganglioside molecular species [LG‐1 (1) and LG‐2 (5)] have been obtained from the water‐soluble lipid fraction of the chloroform/methanol extract of the starfish Astropecten latespinosus. On the basis of chemical and spectroscopic findings, the structure of 1 and 5 have been elucidated. They are new ganglioside molecular species. Negative FAB mass spectrometry provided important information both on the structure of the sugar moiety and on the molecular mass of the gangliosides. Partial hydrolysis by hot water has proved useful for structure elucidation of the complex oligosaccharide moieties. In addition, the major ganglioside molecular species, LG‐2 (5), shows antitumor activity against murine lymphoma L1210 cells in vitro.

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