Biological Synthesis of Lactose from Carbon-14 Glucose
✍ Scribed by FRENCH, T. H.; POPJÁK, G.; MALPRESS, F. H.
- Book ID
- 109569086
- Publisher
- Nature Publishing Group
- Year
- 1952
- Tongue
- English
- Weight
- 113 KB
- Volume
- 169
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/169071a0
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📜 SIMILAR VOLUMES
## Abstract 4‐__C__‐Formylglucopyranoside 9 was readily obtained from 4‐__O__‐unprotected glucose derivative 4 in four steps, each step giving a high product yield. Reaction with 1‐__C__‐lithiated 2‐phenylsulfinyl‐D‐galactal 10 as nucleophile furnished __C__‐disaccharide intermediates 11a and 11b a
Recent enzymic studies Cl-3j have shown that, lactose is synthesized in the presence of substrates, a galactosyltjransferasc and a-lactalbumin. The reaction (equat'ion 1) is essentially irreversible and conditions may Rills+ 'Journal Article 2461 of the Agricultural Experiment Station,
Various Carbon-I4 l a b e l l e d amino acids i n c l u d i n g t h e a r o m a t i c ones viz., t y r o s i n e , phenylalanine and t r y p t o p h a n are converted t o t h e corresponding c a r b o x y l i c acids i n high y i e l d (70 -9M) on a micromolar scale s y n t h e s i s l y r e a c t i