Biological effects and specific membrane receptors for IFN-γ and for tumor necrosis factor on human tumor cells
✍ Scribed by K. Pfizenmaier; P. Scheurich; U. Ücer; M. Krönke
- Book ID
- 112785388
- Publisher
- Springer-Verlag
- Year
- 1986
- Tongue
- English
- Weight
- 136 KB
- Volume
- 111
- Category
- Article
- ISSN
- 1432-1335
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The expression of specific membrane receptors for TNF-alpha was determined on various human leukemic cell lines differing in their sensitivity to the growth-inhibitory activity of TNF-alpha. Binding studies with '251-labelled TNF-alpha indicated specific binding in 8/10 cell lines with approximately
## Abstract A large difference in the number of γ‐IFN receptors was found on a variety of human tumor cell lines with a range of 0.4 to 15 × 10^3^ binding sites/cell. The receptor number did not correlate with the potential responsiveness of the cells to γ‐IFN, in regard to either growth inhibition