Biological effects of γ-interferon on human tumor cells: Quantity and affinity of cell membrane receptors for γ-IFN in relation to growth inhibition and induction of HLA-DR expression
✍ Scribed by Ugur Ücer; Helge Bartsch; Peter Scheurich; Klaus Pfizenmaier
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- French
- Weight
- 521 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
A large difference in the number of γ‐IFN receptors was found on a variety of human tumor cell lines with a range of 0.4 to 15 × 10^3^ binding sites/cell. The receptor number did not correlate with the potential responsiveness of the cells to γ‐IFN, in regard to either growth inhibition or induction of HLA‐DR expression, two independently regulated γ‐IFN effects. However, with respect to HLA‐DR expression it was found that the γ‐IFN sensitivity of inducible cell lines depended on the number of receptors, so that with increasing number of receptors present on these cells lower doses of γ‐IFN were required for induction of the γ‐IFN effect.