Bioinformatics approaches for detecting gene–gene and gene–environment interactions in studies of human disease
✍ Scribed by Ritchie, Marylyn D.
- Book ID
- 124165848
- Publisher
- American Association of Neurological Surgeons
- Year
- 2005
- Tongue
- English
- Weight
- 213 KB
- Volume
- 19
- Category
- Article
- ISSN
- 1092-0684
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Gene‐gene interaction plays an important role in the etiology of complex diseases, which may exist without a genetic main effect. Most current statistical approaches, however, focus on assessing an interaction effect in the presence of the gene's main effects. It would be very helpful to develop met
For complex diseases, the relationship between genotypes, environment factors, and phenotype is usually complex and nonlinear. Our understanding of the genetic architecture of diseases has considerably increased over the last years. However, both conceptually and methodologically, detecting gene-gen