Multifactor dimensionality reduction for detecting gene–gene and gene–environment interactions in pharmacogenomics studies
✍ Scribed by Ritchie, Marylyn D; Motsinger, Alison A
- Book ID
- 120631410
- Publisher
- Future Medicine
- Year
- 2005
- Tongue
- English
- Weight
- 649 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1462-2416
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Gene‐gene interaction plays an important role in the etiology of complex diseases, which may exist without a genetic main effect. Most current statistical approaches, however, focus on assessing an interaction effect in the presence of the gene's main effects. It would be very helpful to develop met
## Abstract The identification and characterization of genes that influence the risk of common, complex multifactorial diseases, primarily through interactions with other genes and other environmental factors, remains a statistical and computational challenge in genetic epidemiology. This challenge