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Bioenergetics shapes cellular death pathways in Leber's hereditary optic neuropathy: a model of mitochondrial neurodegeneration

✍ Scribed by Carelli, Valerio; Rugolo, Michela; Sgarbi, Gianluca; Ghelli, Anna; Zanna, Claudia; Baracca, Alessandra; Lenaz, Giorgio; Napoli, Eleonora; Martinuzzi, Andrea; Solaini, Giancarlo


Book ID
117990599
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
311 KB
Volume
1658
Category
Article
ISSN
0005-2728

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Leber's hereditary optic neuropathy (LHON) is characterized by acute or subacute bilateral (usually permanent) loss of central vision, caused by neuroretinal degeneration. The maternal inheritance is explained by the mitochondrial origin of the disease. Recently, a single mitochondrial DNA (mtDNA) m