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Biochemistry of Cyclooxygenase (COX)-2 Inhibitors and Molecular Pathology of COX-2 in Neoplasia

โœ Scribed by Fosslien, Egil

Book ID
120207267
Publisher
Informa plc
Year
2000
Tongue
English
Weight
952 KB
Volume
37
Category
Article
ISSN
1040-8363

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โœ John J. Talley; Stephen R. Bertenshaw; David L. Brown; Jeffery S. Carter; Mathew ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 96 KB ๐Ÿ‘ 1 views

A series of methysulfonyl or sulfonamido substituted 4,5-diaryloxazole were prepared and evaluated for their ability to inhibit the inducible form of cyclooxygenase (COX-2) in vitro and in vivo. Several unique substitution patterns were identified that led to potent and selective inhibitors of COX-2