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Cyclooxygenase-2 (COX-2)-Independent Anticarcinogenic Effects of Selective COX-2 Inhibitors

✍ Scribed by Grosch, S.; Maier, T. J.; Schiffmann, S.; Geisslinger, G.


Book ID
125833660
Publisher
Oxford University Press
Year
2006
Tongue
English
Weight
765 KB
Volume
98
Category
Article
ISSN
0027-8874

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A series of methysulfonyl or sulfonamido substituted 4,5-diaryloxazole were prepared and evaluated for their ability to inhibit the inducible form of cyclooxygenase (COX-2) in vitro and in vivo. Several unique substitution patterns were identified that led to potent and selective inhibitors of COX-2