3-hydroxy-benzo(a)pyrene (3-OH-B(a)P) and mutagenic activity in rat urine were determined after the oral administration of benzo(a)pyrene given in three repeated doses of 10, 20 and 50 pmol kg-'. The procedure for the determination of 3-OH-B(a)P consisted of enzymic hydrolysis, separation and HPLC-a
Biochemical Responses of Cnidarian Larvae to Mercury and Benzo(a)pyrene Exposure
✍ Scribed by Oriana Farina; Ruth Ramos; Carolina Bastidas; Elia García
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 214 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0007-4861
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The stability of the four benzojalpyrene-7,8,9,10-tetrahydrotetrols is investigated under hydrolysis conditions necessary to release the tetrols from haemoglobin. Two benzo[alpyrene (BP)-tetrols appeared to be rather stable under hydrolysis conditions, whereas two other BP-tetrols were unstable and
## Abstract To understand carcinogenesis of human breast epithelial cells induced by chronic exposure to environmental pollutants, we studied biological and molecular changes in progression of cellular carcinogenesis induced by accumulated exposures to the potent environmental carcinogen benzo[a]py