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Liquid chromatographic analysis and stability of benzo[a]pyrene-tetrols in blood protein adducts in rats after exposure to benzo[a]pyrene

✍ Scribed by Eugène H.J.M. Jansen; Rijk H. van den Berg; E. Dinant Kroese

Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 534 KB
Volume: 290
Category: Article
ISSN: 0003-2670
DOI: 10.1016/0003-2670(94)80043-x

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✦ Synopsis

The stability of the four benzojalpyrene-7,8,9,10-tetrahydrotetrols is investigated under hydrolysis conditions necessary to release the tetrols from haemoglobin. Two benzo[alpyrene (BP)-tetrols appeared to be rather stable under hydrolysis conditions, whereas two other BP-tetrols were unstable and were transformed (partially) into the former two tetrols. In addition a method of analysis of BP-tetrols hydrolysed from rat haemoglobin adducts of rats exposed to BP is indicated and discussed.

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