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Toxic response of hamster embryo cells on exposure to mixtures of Ni2+ and benzo(a)pyrene

✍ Scribed by M. Uziel; B. Owen; A. Butler

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
386 KB
Volume
6
Category
Article
ISSN
0260-437X

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✦ Synopsis

Exposure of hamster embryo cells (HEC

) to mixtures of benzo(a) pyrene and soluble Ni2' neutral salts elicits additive responses in the enhanced nucleoside excretion assay. Ni2+ shows no significant excretion response until concentrations near 10 ~L M are reached. Addition of 0.4 micromolar benzo(a)pyrene and 30 p ~, or 325 p~ Ni2+ to HEC cultures results in total excretion equal to the sum of excretions induced by the individual chemicals. These observations suggest that excretion of pyrimidines may be a useful measure of biological dosimetry.

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