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Biochemical and toxicological studies on the effect of high and low erucic acid rapeseed oil on rats

✍ Scribed by Badawy, I. H. ;Atta, B. ;Ahmed, W. M.


Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
603 KB
Volume
38
Category
Article
ISSN
0027-769X

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✦ Synopsis


Rats were fed on diets containing rapeseed oil, either containing low or high erucic acid content as well as the hydrogenated ones for 6 weeks. Body weight gain. biochcmical and pathological parameters were investigated. The data showed high body weight gain for rats fed diets containing low erucic rape oil (LERo) compared with those fed either the high erucic rape oil (HERO), the hydrogenated or the partially hydrogenated oil diets. All rats showed noti significant changes for total lipids, total cholesterol, GPT and GOT, except the partially hydrogenated rape oil dict which showcd significant decrease for total cholesterol. Alkaline phosphatase however showed a significant decrease, while plasma phospholipids showed significant increase in rats fed on the hydrogenated oil diet. Triglycerides indicatcd non significant incrcase except in the group that received low erucic rapc oil diet. Histopathological study showed changes in all tissues examined (liver and kidney).

Zusamrnenfassung

Biochemische und toxikologische Untersuchungen iiber den EinfluD von erucasiurcreichen und -armen Rapsolen auf Ratten.

Ratten erhielten 6 Wochen lang Diiiten, die erucasaurearmes bzw. -reichcs sowie hydriertcs Rapsol enthielten. Es wurden die Gewichtszunahme verfolgt und biochemische und pathologkche Parameter hestimmt. Ratten, die eine Diiit mil erucasiurearmcm Rapsol erhalten hatten, wiesen eine hohere Gewichtszunahme auf als solche, die Dilten rnit erucasiurcrcichem, hydricrtcm oder partiell hydriertem 0 1 erhieltcn. Alle Ratten zeigten keine signifikanten Verinderungen bci den Gesamtlipidcn, bet Gesamtcholesterol, G P T und GOT; lediglich bei Ratten snit der Diiit rnit partiell hydriertem Rapsol war eine signifikmte Abnahme im Gesamtcholesterolgchalt zu verzcichnen. Bei Ratten rnit der Diiit rnit hydriertem 01 nahm die alkalische Phosphatase signifikant ab, die Plasmaphospholipide nahmen signifikant zu. Triglyceride zeigten keinen signjfikanten Anstieg; einc Ausn, ' 1 h me bildctcn Ratten der Gruppc, die die D i i t mit crucasiurearmcm 0 1 erhalten hatte. Histopathologische Untersuchungen zeigten in allen gcpruften Geweben (Lebcr, Niere) Verinderungen.


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