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Biochemical and immunohistological changes in the brain of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mouse

✍ Scribed by Tsutomu Araki; Tadayoshi Mikami; Hiroaki Tanji; Mitsunobu Matsubara; Yutaka Imai; Michinao Mizugaki; Yasuto Itoyama


Book ID
114301803
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
580 KB
Volume
12
Category
Article
ISSN
0928-0987

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP