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Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253

✍ Scribed by Dr. B. Kenneth Koe; Jann A. Nielsen; John E. Macor; James Heym


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
549 KB
Volume
26
Category
Article
ISSN
0272-4391

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Synthesis of [3H]CP-93,129: A selective
✍ John E Macor; Kevin Ryan; Phillip M. Chalabi; James C. Windels; Robert W. Roth πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 French βš– 413 KB

## Abstract The synthesis of [^3^H]‐CP‐93,129, a potent radioligand for the serotonin 5‐HT~1B~ receptor, is described. 5‐Butoxypyrrolo[3,2‐b]pyridine (2) is converted in 3 steps to 5‐butoxy‐1‐phenylsulfonyl‐2‐tritiopyrrolo[3,2‐b]pyridine (3c) via lithiation of C2, iodination of that anion, and trit