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Biocatalyzed irreversible esterification in the preparation of S-naproxen

✍ Scribed by R. Morrone; N. D’Antona; D. Lambusta; G. Nicolosi

Book ID
113804627
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
279 KB
Volume
65
Category
Article
ISSN
1381-1177

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Lipase-catalyzed enantioselective esteri
Lipase-catalyzed enantioselective esterification of S(+)-naproxen ester prodrugs in cyclohexane
✍ Shau-Wei Tsai; Shiang-Fei Lin; Chun-Sheng Chang 📂 Article 📅 1999 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 125 KB 👁 2 views

A lipase-catalyzed enantioselective esteri®cation process in cyclohexane was developed for the synthesis of S( )-naproxen ester prodrugs containing the moiety of N,N-dialkylamino, ethylene glycol or alkyl ether of ethylene glycol. A high enantiomeric ratio of 44 was obtained when di(ethylene glycol