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A facile enzymatic resolution process for the preparation of (+)-S-2-(6-hethoxy-2-naphthyl)propionic acid (Naproxen).

✍ Scribed by Qu-Ming Gu; Ching-Shin Chen; C.J Sih


Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
220 KB
Volume
27
Category
Article
ISSN
0040-4039

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Process for the preparation of 2-(S)-pip
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Continuous resolution of 2-piperazinecarboxylic acid 2 with (S)-camphor-10-sulfonic acid as resolving and epimerisation agent affords 2-(S)-piperazinecarboxylic acid (S)-dicamphor-10-sulfonate 3 in 62% isolated yield and >99% ee. (~) 1997 Elsevier Science Ltd Optically active amino acids and derivat