Procedure for the Parallel Preparation of 3-Imidazo[1,2-a]pyridin-3-yl-propionic Acid Derivatives Involving Meldrum′s Acid.
✍ Scribed by Janos Gerencser; Gabor Panka; Tamas Nagy; Orsolya Egyed; Gyoergy Dorman; Laszlo Uerge; Ferenc Darvas
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 22 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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## Abstract A novel chiral stationary phase (CSP) for HPLC was prepared by bonding (__R__)‐1‐phenyl‐2‐(4‐methylphenyl)ethylamine amide derivative of (__S__)‐valine to aminopropyl silica gel through a 2‐amino‐3,5‐dinitro‐1‐carboxamido‐benzene unit. The CSP was used for the separation of some amino a
The title compound has been prepared as its N-benzyloxycarbonyl urethane in a three-step one-pot reaction in 20-30% yield from the dipeptide derivative Z-Gln-Glu(OH)2. Evidence concerning the configuration and chiral purity of the title compound is given.