Process for the preparation of 2-(S)-pip
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Klaus Stingl; Matthias Kottenhahn; Karlheinz Drauz
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Article
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1997
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Elsevier Science
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English
โ 195 KB
Continuous resolution of 2-piperazinecarboxylic acid 2 with (S)-camphor-10-sulfonic acid as resolving and epimerisation agent affords 2-(S)-piperazinecarboxylic acid (S)-dicamphor-10-sulfonate 3 in 62% isolated yield and >99% ee. (~) 1997 Elsevier Science Ltd Optically active amino acids and derivat