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Lipase-catalyzed enantioselective esterification of (S)-naproxen hydroxyalkyl ester in organic media

โœ Scribed by Chun-Sheng Chang; Chin-Shuo Hsu

Book ID
110429408
Publisher
Springer Netherlands
Year
2003
Tongue
English
Weight
62 KB
Volume
25
Category
Article
ISSN
0141-5492

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Lipase-catalyzed enantioselective esteri
Lipase-catalyzed enantioselective esterification of S(+)-naproxen ester prodrugs in cyclohexane
โœ Shau-Wei Tsai; Shiang-Fei Lin; Chun-Sheng Chang ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 125 KB ๐Ÿ‘ 2 views

A lipase-catalyzed enantioselective esteriยฎcation process in cyclohexane was developed for the synthesis of S( )-naproxen ester prodrugs containing the moiety of N,N-dialkylamino, ethylene glycol or alkyl ether of ethylene glycol. A high enantiomeric ratio of 44 was obtained when di(ethylene glycol