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Bioavailability of fluvoxamine given with and without food

✍ Scribed by J. Van Harten; P. Van Bemmel; M. R. Dobrinska; R. K. Ferguson; M. Raghoebar

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
298 KB
Volume
12
Category
Article
ISSN
0142-2782

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✦ Synopsis

Abstract

The influence of concomitant food intake on plasma concentrations of the antidepressant drug fluvoxamine maleate was investigated in a two‐way, crossover study design. Eight male and four female healthy, young volunteers received a single oral dose of fluvoxamine maleate (50 mg, tablet) on two occasions: after an overnight fast and immediately after a breakfast. Food did not affect maximum fluvoxamine plasma levels (C~max~), or the time to reach C~max~ (t~max~). The plasma AUC of fluvoxamine was on average 7 per cent lower in the fed than in the fasted state. It is concluded that the effect of food on the pharmacokinetics of fluvoxamine is negligible.

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