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Binding specificity of chemically and enzymatically activated anthracycline anticancer agents to nucleic acids

✍ Scribed by Birandra Kumar Sinha

Book ID
113136216
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
642 KB
Volume
30
Category
Article
ISSN
0009-2797

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## Abstract A free radical was produced enzymatically by incubating benzo(a)pyrene with liver microsomes. This radical, identified as the 6‐oxybenzo(a) pyrene radical, was sufficiently reactive to bind covalently with nucleic acid bases. Similar reactive free radicals were produced enzymatically fr