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Binding of the Antitumor Drug Nogalamycin to Bulged DNA Structures †

✍ Scribed by Caceres-Cortes, Janet; Wang, Andrew H.-J.


Book ID
126264652
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
534 KB
Volume
35
Category
Article
ISSN
0006-2960

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The structural selectivity of the DNA-binding antitumor drug ditercalinium was investigated by competition dialysis with a series of nineteen different DNA substrates. The 7H-pyridocarbazole dimer was found to bind to double-stranded DNA with a preference for GC-rich species but can in addition form