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Voltammetric and spectroscopic studies on the binding of the antitumor drug dacarbazine with DNA

✍ Scribed by Radi, Abd-Elgawad; Eissa, Alsayed; Nassef, Hossam M.


Book ID
121688069
Publisher
Elsevier
Year
2014
Tongue
English
Weight
722 KB
Volume
717-718
Category
Article
ISSN
1572-6657

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The structural selectivity of the DNA-binding antitumor drug ditercalinium was investigated by competition dialysis with a series of nineteen different DNA substrates. The 7H-pyridocarbazole dimer was found to bind to double-stranded DNA with a preference for GC-rich species but can in addition form