Inorganic mercury, administered to rats in a single dose of 0.5 mg Hg/kg is accumulated in the kidneys mainly in the soluble (54%) and nuclear (30%) fractions, showing decreasing tendency with time. Mitochondrial and microsomal fractions, initially accumulating approx. 11 and 6% of total Hg, show a
Binding of mercury and selenium in subcellular fractions of rat liver and kidneys following separate and joint administration
✍ Scribed by Elżbieta Komsta-Szumska; Jadwiga Chmielnicka
- Publisher
- Springer-Verlag
- Year
- 1977
- Tongue
- English
- Weight
- 630 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0340-5761
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✦ Synopsis
The distribution of mercury and selenium has been examined in subcellular fractions of rat liver and kidneys in prolonged exposure to HgCl2 and Na2SeO3 administered separately and simultaneously. The molar ratio of mercury and selenium concentrations in subcellular fractions of the organs examined varied considerably. Selenium displaced mercury from the soluble kidney fraction bound mainly with metallothionein to the nonhistone protein fraction of liver nuclei. The Hg-stimulated biosynthesis of metallothionein has been eliminated under the influence of selenium.
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