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Binding of inorganic mercury by subcellular fractions and proteins of rat kidneys

✍ Scribed by Elżbieta Komsta-Szumska; Jadwiga Chmielnicka; J. K. Piotrowski

Publisher
Springer-Verlag
Year
1976
Tongue
English
Weight
448 KB
Volume
37
Category
Article
ISSN
0340-5761

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✦ Synopsis

Inorganic mercury, administered to rats in a single dose of 0.5 mg Hg/kg is accumulated in the kidneys mainly in the soluble (54%) and nuclear (30%) fractions, showing decreasing tendency with time. Mitochondrial and microsomal fractions, initially accumulating approx. 11 and 6% of total Hg, show a tendency to increase the absolute level of Hg for the first week after administration. In the soluble fraction low-molecular weight, metallothioneinlike proteins are mainly responsible for the accumulation of mercury, in other fractions proteins of higher molecular weight prevail.

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