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Binding characteristics and analgesic activity of D-Ala2-Leu5-enkephalin chloromethyl ketone

✍ Scribed by Mária Szücs; Sándor Benyhe; Anna Borsodi; Mária Wollemann; Gábor Jancsó; Judit Szécsi; Kálmán Medzihradszky

Book ID
118941915
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
435 KB
Volume
32
Category
Article
ISSN
0024-3205

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Synthesis of 3H-D-ala2-leu-enkephalin-chloromethyl ketone of high specific activity
✍ G. Tóth; J. Hepp; F. Sirokmán; K. Medzihradszky 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 French ⚖ 283 KB

Boc-Tyr-D-Ala-Gly was prepared by catalytic tritiation of protected, iodinated tripeptide. The protected tritiated tripeptide and the Phe-Leu-CH2C1 dipeptide were condensed by the mixed anhydride method. The p r o - 3 " tecting group was removed by HC1-methanol. The /JH/-DALECK had a specific activi