Cerebrospinal fluid pharmacokinetics of
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Dwight E. Moulin; Charles E. Inturrisi; Dr Kathleen M. Foley
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Article
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1986
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John Wiley and Sons
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English
⚖ 488 KB
Using an implantable pump system to deliver drugs and sample cerebrospinal fluid (CSF), we assessed rostral redistribution and systemic uptake after intrathecal bolus injection and steady-state infusion of morphine sulfate and the opioid peptide ~A l a ~-~L e u ~-e n k e p h a l i n (DADL) in two pa