with low dose LV. Based on these reports, a first-line Phase II study was performed in 101 patients with advanced colorectal carcinoma who were given a bimonthly
Bimonthly 24 h Infusion of High-Dose 5-Fluorouracil vs EAP Regimen in Patients with Advanced Gastric Cancer
✍ Scribed by I. P. Popov; S. B. Jelić; Z. V. Krivokapić; S. D. Jezdić; P. M. Peško; M. T. Micev; D. R. Babić
- Book ID
- 107576620
- Publisher
- Springer US
- Year
- 2007
- Tongue
- English
- Weight
- 110 KB
- Volume
- 25
- Category
- Article
- ISSN
- 1357-0560
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## BACKGROUND. Reports of in vitro experiments in colorectal carcinoma cells suggest that prolonged cellular exposure to 5-fluorouracil (5-FU) combined with relatively low concentrations of leucovorin (LV) provides optimal enhancement of 5-FU efficacy. In this study, a simplified regimen of weekly