Bile acids induce hepatic stellate cell proliferation via activation of the epidermal growth factor receptor
β Scribed by Gianluca Svegliati-Baroni; Francesco Ridolfi; Rebekka Hannivoort; Stefania Saccomanno; Manon Homan; Samuele de Minicis; Peter L.M. Jansen; Cinzia Candelaresi; Antonio Benedetti; Han Moshage
- Book ID
- 119758339
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 898 KB
- Volume
- 128
- Category
- Article
- ISSN
- 0016-5085
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Abbreviations: HSC, hepatic stellate cells; β£-SMA, β£ smooth muscle actin; PDGF, platelet-derived growth factor; PPARβ₯, peroxisome proliferator-activated receptor β₯; 9-cisRA, 9-cis retinoic acid; RXR, retinoic X receptor; 15d-PGJ 2 , 15-deoxy-β¬ 12,14 prostaglandin J 2 ; [ 3 H]TdR, [methyl-3 H]thymidi
Platelet-derived growth factor (PDGF) is the most potent mitogen for hepatic stellate cells (HSCs) in vitro. The aim of this study was to investigate the role of the lipid-derived second messenger phosphatidic acid (PA) in mediating this effect and, in particular, to determine its interaction with t